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In the pediatric population, certain genetic variants have been linked to a higher risk of developing various types of toxicity, including gastrointestinal, hematological, neurological, endocrine, and cardiotoxic effects [69]
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Turjeman, K
By international agreement, standardized methods have been used to characterize these enzyme variants, which differ on the basis of biochemical properties such as kinetic activity, electrophoretic mobility, the Michaelis constant for its substrate glucose-6-phosphate and cofactor NADP, the ability to utilize different substrate analogues, heat stability, and pH optima
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