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10.1089/ars.2013.5236 70 WangQ.ZhanS.LiuY.HanF.ShiL.HanC.et al (2021)
Thus, it is pivotal that novel clinical and preclinical studies on animal models of AD will intervene as preventive treatments with more effective therapies and will focus on early targets that play a clear role in the development of the disease (e.g., cholinergic drugs which can inhibit the enzyme that degrades acetylcholine, and intracellular clearance mechanisms, such as autophagy) (Dubois et al., 2014
Calibration and validation results As explained in the Methods section, we explored different grouping cases in forming the calibration and validation sets for the control and rd1 data
The studys findings revealed that aberrant hyperphosphorylation could lead to transient memory deficits along with peripheral neuropathy in the form of small-fiber and large-fiber neuropathy with tactile allodynia, altered thermal response, the slowing of motor-nerve-conduction velocity, and a reduction in intra-epidermal-nerve-fiber density (Marquez et al., 2021)
Still, Best cautions that not enough research has been done on this end
