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All surgical interventions, and postoperative animal care conformed to the Animal Care and Use Committee of Wenzhou Medical University

The updated 2018 diagnostic criteria for PCOS require the presence of at least two of the following three features: (1) oligo/anovulation, (2) clinical and/or biochemical hyperandrogenism, and (3) PCO identified by the presence of 20 antral follicles per ovary on transvaginal ultrasound, with or without increased ovarian volume

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This is a blunt intervention applied to a process that is local, mechanically regulated, and tissue-specific

Sustained receptor engagement allows continuous activation of satiety pathways without repeated peaks and troughs