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[16] Melatonin's concentration in the mitochondrial matrix is significantly higher than that found in the blood plasma, [17] [19] emphasizing its role not only in direct free radical scavenging but also in modulating the expression of antioxidant enzymes and maintaining mitochondrial integrity

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doi: 10.1186/s13045-023-01453-1 140 LingZ-NJiangY-FRuJ-NLuJ-HDingBWuJ

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Limitations: Lower Bioavailability: Even with liposomal forms, absorption may not match IV levels