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Since the participants were discouraged from starting symptomatic therapy during the 52-week, Part 1, double-blind, placebo-controlled period unless deemed clinically essential, most participants experienced motor worsening before starting symptomatic therapy, which may not be replicable in future clinical trials with different study designs or population characteristics

TZP was started at 2.5 mg once a week and progressively titrated by 2.5 mg every four weeks

10.1016/j.mam.2012.10.010 Mol