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Discoloration (yellowing or browning), a visibly collapsed or shrunken cake, or powder that appears clumped and unevenly distributed can all indicate that a vial was exposed to conditions outside its intended storage range most commonly heat, light, or moisture ingress even if the vial appears sealed
Cell1998 Feb 20;92(4):573-85
The -1 subcluster exhibited increased expression of several mitochondrial genes as well as stress-related genes, such as XBP1 , ferritin heavy chain 1 ( FTH1 ), and ferritin light chain ( FTL ), in response to liraglutide treatment
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