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Metabolic and hormonal effects Reproductive health Bone and cardiovascular health Neuropsychiatric considerations Future research and clinical implications Conclusion Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were initially developed to regulate blood glucose levels in patients with type 2 diabetes mellitus (T2DM)

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Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

Angesichts der offensichtlich positiven Auswirkungen, die sich derzeit fr eine Behandlung der Adipositas mit GLP-1-RA oder Weiterentwicklungen abzeichnen, wre es wnschenswert, die Sinnhaftigkeit dieses grundstzlichen Ausschlusses neu zu diskutieren