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Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress
Key Points Glucocorticoids modulate growth hormone (GH) secretion at both the hypothalamic and pituitary level Hypoadrenalism might cause GH deficiency that is reversible during glucocorticoid replacement therapy Testing for GH deficiency in patients with hypopituitarism should always be performed after adequate periods of cortisol replacement Chronic excess of glucocorticoids, either exogenous or endogenous, causes GH deficiency that might be involved in metabolic and cardiovascular complications Treatment with recombinant GH could be considered in children and adults with glucocorticoid-induced GH deficiency This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF
and microorganism like cyanobacteria, in attempt to improve the stress tolerance further and overcome the limitations of possessed by GSH in conferring growth and yield of plants (Semida et al., 2018
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Finally, after an omics biomarker is discovered and analytically verified, the biomarker or pattern of biomarkers needs to be further evaluated in additional nonclinical and clinical studies to determine time domain, limitations of use and whether they are truly translational
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