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3.1.3 DON DON (6-diazo-5-oxo-l-norleucine), a glutamine analog, irreversibly inhibits various glutamine utilization enzymes, such as glutaminase and glutamine synthetase, by forming covalent bonds with nucleophilic residues on the active site of the enzyme (Rajagopalan and DeBerardinis, 2011
Generic availability also reduces payer resistance, since the per-member cost has dropped below many specialty drug thresholds
The recommended daily intake for adults is 310 mg to 420 mg, according to the Office of Dietary Supplements
If it can demonstrate superior MACE reduction, it will shift to first line in cardiovascular prevention in obese patients
The efficiency of Coxs likelihood function for censored data
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