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It is often considered for people with a BMI of 30 or higher, or 27 or higher with a weight-related health condition
The mechanistic basis involves GHK-CuCuSOD1 (cytoplasmic Cu/Zn-SOD) enhanced activity (NBT reduction assay: +31 5%), reducing HO-driven JNK activation via ASK1-Thr845 phosphorylation (ThioredoxinReductase-Trx1 redox buffer maintained)
10.1096/fj.10-162438 FASEB J
FDA briefing document US Food and Drug Administration
Cell 179(4):813-827
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