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Women are three to four times more likely than men to experience migraines, as hormones appear to play a key role

Sukumaran D, et al

Stopping earlier is not necessary from a pharmacokinetic standpoint but gives you psychological confidence and time to establish baseline weight and glucose patterns before conception

But theres also no universal answer

The primary objective of this meta-analysis was the comparison of the time to first occurrence of confirmed four-component major adverse cardiovascular events including cardiovascular death, myocardial infarction, stroke and hospitalized unstable angina between tirzepatide groups and control groups