The concurrent engagement of all three receptors is hypothesised to produce complementary metabolic effects in pre-clinical models: GLP-1R activation is associated with glucose regulation and appetite modulation, GIPR activation with potentiation of GLP-1mediated responses, and GcgR activation with energy expenditure and hepatic lipid metabolism in laboratory settings
Back Syn, NL, Cummings, DE, Wang, LZ, et al (2021) 'Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants', The Lancet , 397, 1830-41
STAT6 and lung inflammation
Individual responses vary significantly
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