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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome
Elderly people due to impaired intestinal absorption and children, premenopausal women, and pregnant women whose diets are low in animal foods are all at increased risk
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