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Even for beneficiaries with severe obesity and multiple weight-related health conditions, Medicare cannot cover medications prescribed specifically for weight loss
Lancet (2019) 394(10192):3950
The reta + cag stack swaps semaglutide for retatrutide - which already hits three receptors - aiming to layer amylin satiety on top of broader metabolic effects
This means pyridoxine may provide proportionally greater benefit for semaglutide users than tirzepatide users, simply because the baseline nausea burden is higher
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