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Diabetes Obes Metab 14:514 Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, The PROactive Investigators (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone clinical trial in macro vascular events): a randomised controlled trial

Essentially, this design emulated a randomised controlled trial, in which participants on a background therapy with one of the drug classes of interest (GLP-1 receptor agonists or SGLT-2 inhibitors) are randomised to either continue the background drug or add on the other drug of interest (SGLT-2 inhibitor or GLP-1 receptor agonist, respectively)

Higher efficacy may justify premium pricing for patients seeking aggressive metabolic intervention, though individual response varies widely based on genetic factors and baseline health status

The product is available in a pack of 5 vials of 5 milliliters of powder to be diluted each