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On rare occasions when needed, they still created individualized concoctions but the number of prescriptions that required some kind of compounding dropped from 75% in the 1930s to less than 5% by 1960

5-amino-1MQ has a 46 hour half-life requiring daily administration to sustain NNMT inhibition

Simple math, consistent dosing

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doi:10.3945/ajcn.2008.26947D