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Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance
This depletion compromises cellular defense mechanisms and contributes to numerous age-related pathologies including neurodegenerative diseases, cardiovascular dysfunction, metabolic disorders, and impaired immune function
Crit Rev Toxicol
In addition, the high expression of NRF2 enhances the expression of downstream SOD1, an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative damage [36]
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