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5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions
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[PMID: 34408103] PubMed record related to this compound for laboratory literature review
Beyond sequence, epigenetic evidence points to an NNMT-linked signature in human adipose tissue, indicating the pathway is dynamically active in human fat biology, not only in laboratory animals
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