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We found that both ( S,S )-ACPC-containing analogues could function as antagonists of GLP-1-induced cAMP production in HEK293GS22 cells
Intraperitoneal injection of the DREADD agonist clozapine N -oxide (CNO) induced robust c-Fos expression in LS GLP-1R neurons transduced with hM3D, indicating increased neuronal activity (Figure 5B)
3b,c, Supplementary Movie 2)
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