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Direct receptor expression in human coronary endothelial and smooth-muscle cells has been difficult to confirm using validated antibodies, raising the possibility that some vascular effects are mediated indirectly through circulating immune cells, hepatic signaling, or central-nervous-system pathways [14]

A systematic review and meta-analysis suggests obesity predicts onset of chronic kidney disease in the general population

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PMCID: PMC2885294

Pushing through excessive fatigue during aggressive fat loss protocols leads to overtraining syndrome, which actually increases muscle catabolism and slows fat loss