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Reconstitute and handle in accordance with standard laboratory safety protocols

Pause-and-resume short 3-5 day breaks when site reactions persist or flushing becomes socially intrusive

Importantly, patients should never feel they have 'failed'obesity is a chronic disease requiring ongoing management, and treatment plans should be individualised and adjusted as needed

Peer review Peer review information Nature Mental Health thanks Karolina Skibicka and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Tranexamic acid does cross the placenta and appears in cord blood at concentrations approximately equivalent to the maternal concentration