However, those who have a condition that affects the bodys ability to absorb B12 may need to continue treatment long-term to manage their B12 levels.
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doi:10.1002/14651858.CD012614.pub2
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Research by Reinstatler and colleagues (2012, Diabetes Care) found that among people taking metformin at doses of 1,000 mg per day or more, the prevalence of B12 deficiency was 5.8 percent