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A defect in collagen polymerization was reported in homocystinuric patients with severe hyperhomocysteinemia (Lubec et al, 1996a)

Self-reported community protocols commonly describe once-daily dosing with on/off cycling, motivated partly by the absence of any long-term human safety data and partly by a community perception of diminishing returns or tolerance over continued use

For completeness, it is important to note that tap water is entirely unsuitable for injection and carries serious infection risks

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Food levels are nanomoles, but supplements provide much larger doses in milligrams