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Description

[Abstract] Mice were subcutaneously administered either Veh, 30 nmol/kg Retatrutide, or 30 nmol/kg SEMA every other day before the initiation of the dark cycle at 5 pm

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The culture supernatant was harvested by centrifugation at 6000 g for 20 min and clarified by filtration

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Combining aerobic exercise with resistance training (23 sessions weekly) helps preserve metabolic rate by maintaining muscle mass

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