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Psychiatry 10 , 284293 (1968)

In term of transport efficiency the best substrate is the synthetic compound TEA, whereas carnitine is a poor substrate (Yabuuchi et al., 1999

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Without adequate B12, these vital processes falter, and fatigue is often one of the earliest and most noticeable symptoms

Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions