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Unlike exogenous GH, sermorelin does not bypass the hypothalamic-pituitary axis, so side effects such as carpal tunnel syndrome, insulin resistance, edema, and joint pain are rare

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This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

doi: 10.1155/2016/9626427 147 AhmadSFAkoumAHorneAW