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This may occur due to factors such as dose level, calorie intake, metabolic adaptation, or reduced physical activity

Allergy to sitagliptin or any inactive ingredient Severe kidney disease or dialysis History of heart failure or pancreatitis Alcohol use, gallstones, high triglycerides Pregnancy or plans to become pregnant Breastfeeding or plans to breastfeed What drug interactions are there with Januvia

Selenium deficiency is associated with pro-longevity mechanisms

Mechanisms such as accelerated cell turnover or altered gut microbiota composition caused by GLP-1 RA use may be part of the elevated risk observed in the context of colorectal cancer

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