A study published in Diabetes, Obesity and Metabolism in January 2025 followed 262 patients treated with GLP-1 agonists in Ireland
Weight Loss Outcomes After Switching Trial data supports a higher average weight loss ceiling on tirzepatide: 20.9% at 72 weeks on 15mg (SURMOUNT-1) versus 14.9% at 68 weeks on 2.4mg semaglutide (STEP 1)
Regulatory & Use: For laboratory research only
Fifty-six clinical trials were identifiedorlistat (22), semaglutide (14), liraglutide (11), tirzepatide (6), naltrexone/bupropion (5) and phentermine/topiramate (2)enrolling 60,307 patients (32,598 OMM and 27,709 placebo)
Any future retatrutide prescribing guidance would define its own stopping criteria in its Summary of Product Characteristics (SmPC) and any relevant NICE technology appraisal, if licensed