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Consistent with the incretin-mediated delivery of the PPAR// agonist, the metabolic effects of GLP-1GIPLani were blunted in DIO mice with pharmacological or genetic inhibition of GLP-1R, GIPR or PPAR, and vanished in double-incretin receptor knockout (DIR-KO) mice

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Brass EP, Hiatt WR

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It can be corrected by turning the dose knob in either direction until the prime position lines up to the dose indicator

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