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They act on completely different receptor pathways to produce the same end result (growth hormone release)

Figure 4: Reduction in body weight from baseline level in treatment groups administered treatment with cagrilintide, semaglutide, or a combined treatment of both peptides

A pro-inflammatory state is created within the body through the stimulation of cytokines (pro-inflammatory molecules)

In conclusion, both SGLT2-i and GLP1-RA seem to have several effects on RAAS, though additional studies are needed to clarify this relationship