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58 We developed a competition assay based on detection of probe binding via bioluminescence resonance energy transfer (BRET)

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Research published in cardiovascular journals has shown that patients on semaglutide experienced average LDL reductions of 515% and triglyceride reductions of 1025% over 612 months

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Discovery work characterised it as roughly 0.4 as active as native GLP-1, 0.3 as active as native glucagon and about 8.9 as active at the GIP receptor [6]