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Plasma GLP-1 concentrations (pg/mL) were significantly decreased in cocaine-experienced rats versus yoked-saline controls following 21 days of self-administration (Fig 1B) and acute withdrawal (i.e., extinction day 1) (Fig 1C)

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Uremic toxins induce kidney fibrosis by activating intrarenal reninangiotensinaldosterone system associated epithelial-to-mesenchymal transition