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Applications include dehydrogenase and oxidoreductase assays monitored at 340 nm, sirtuin deacylase activity assays, PARP and ADP-ribosyltransferase reactions, CD38 and NADase kinetics, NAD+/NADH ratio measurement as a readout of cytosolic and mitochondrial redox state, and cellular ageing research where tissue NAD+ decline has been attributed largely to increased consumption by CD38 (Camacho-Pereira et al., Cell Metabolism, 2016) and quantified by stable-isotope flux analysis (Liu et al., Cell Metabolism, 2018)
When designing comprehensive peptide protocols, practitioners might also consider complementary compounds available from specialized peptide suppliers to address multiple therapeutic targets simultaneously
Because of its many characteristics and functions, this tripeptide can rightly be considered a super-molecule, essential for the functioning of our antioxidant and immune systems
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