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Common gastrointestinal side effects include: Nausea (1222% of patients, dose-dependent) Diarrhea (1316% of patients) Vomiting (69% of patients) Constipation (67% of patients) Abdominal pain or discomfort (69% of patients) Decreased appetite (59% of patients) These effects are generally mild to moderate in severity and most pronounced during dose escalation

Natural Fiber (especially soluble fiber) slows digestion, prolongs satiety, and triggers GLP-1 release

Onglyza (saxagliptin): US prescribing information

However, repeatedly taking doses early shortens your effective dosing interval and can lead to cumulative medication buildup

The co-formulation supports research into how these anti-inflammatory and repair signals interact at the cellular level