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However, owing to the lack of consideration for brain capillary binding or sequestration, the reliability of these results regarding brain uptake pharmacokinetics has been questioned [21] as well as whether results could be translated into humans

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It works by activating two hormone receptors that play a significant role in appetite regulation and metabolic control: GLP-1 and GIP

Beyond circulating mediators, the hypothalamus functions as the primary lipid-sensing hub that detects and responds to lipid overload in the brainperipheral axis

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