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REIMAGINE 2 was a 68-week efficacy and safety phase 3 trial of CagriSema 2.4 mg/2.4 mg and 1 mg/1 mg once-weekly versus semaglutide 2.4 mg, semaglutide 1 mg, cagrilintide 2.4 mg, and placebo in 2,713 adults with type 2 diabetes inadequately controlled with metformin with or without an SGLT2 inhibitor

This minimizes enzymatic degradation and competition for absorption in the GI tract, ensuring a more consistent dose reaches circulation

The animals were restrained with their heads positioned downward and abdomens upward for the i.p