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The SURMOUNT-1 DXA substudy found that tirzepatide produced a 33.9% reduction in fat mass and a 10.9% reduction in lean mass over 72 weeks, with approximately 75% of total weight lost coming from fat and 25% from lean mass

But as the top players in the fast-growing GLP-1 market, both could deliver excellent returns over the medium term

When to Consider Resuming or Switching to Different GLP-1 Therapies Some patients find that weight regain occurs despite genuine effort to maintain behavioral changes, particularly those with genetic predispositions toward rapid appetite return or metabolic resistance

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