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In all the five studies, an oral (Delpres study via sublingual route) dose of 1000 g vitamin B 12 was used with the exception of Kuzminskis study, whereby a higher dose of 2000 g was used
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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases
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