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Joint pain (chronic knee, shoulder, hip): Anti-inflammatory effects can begin at 2 to 3 weeks

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Common hypothyroidism symptoms can include: Fatigue and lethargy Brain fog and memory issues Constipation Dry skin Thinning hair or loss of the outer portion of eyebrows Unexplained weight gain Joint pain or stiffness Mood swings and depression Sensitivity to cold temperatures Irregular menstrual cycles Infertility What Causes Hypothyroidism

This highlights the potential to exploit HO-1 as a valuable target for therapeutic intervention in DFU cases (Fig