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For rare disease M&A, ODE status must be confirmed at the indication level, not just the drug level, because a single drug can hold multiple orphan designations for different conditions

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The gastrointestinal effects result primarily from delayed gastric emptying and altered gut motility

Solvent selection and all handling are determined by the receiving laboratory under its own protocols

In some cases, products marketed as compounded GLP-1s by bad actors have been found to be counterfeit or to contain ingredients other than what is advertised meaning they may not even be real GLP-1 drugs at all