Future studies need to move beyond the linear explanatory framework based on a single metabolite or a single enzyme and systematically clarify, from the perspectives of temporal resolution and tissue niche resolution, the cooperative relationships between different amino acid metabolic axes and the TCA cycle, OXPHOS, and other immunometabolic modules (139)
Replenishment of GSH by its prodrugs treatment beneficially altered epigenetic enzymes, and VD-metabolism genes in hepatocytes
Mitochondrial metabolic dysfunction reduces GSH production, impairs GPx4-mediated LPO clearance, and predisposes cells to ferroptosis (118)
Yes, topical glutathione is generally considered safe for daily use
As such, glutathione may help even out the appearance of dark skin patches that appear with aging [69, 70]