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The SCS is composed of a single layer of LECs interspersed with macrophages and dendritic cells that collect lymph, and this single-layer structure can impede lymph from entering the lymph node parenchyma and guide lymph to diffuse through the cortical sinuses [24, 25]

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Integral to cellular functions like signaling, membrane fluidity, and lipid/protein transport, they safeguard membrane integrity and cellular contents