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This structural feature gives the peptide exceptional stability and resistance to breakdown by digestive enzymes, setting it apart from most other therapeutic peptides

Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

The rate increases with higher doses: 12-14% at 0.5 mg, 23-24% at 2.4 mg

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In this regard, hydrogen peroxide is converted into the hydroxyl radical, a harmful and highly reactive ROS, in the presence of transition metals such as iron (Figure 1)