Here, we use a pooled, dual CRISPR screening strategy that knocks out pairs of transporters in four metabolic states glucose, galactose, OXPHOS inhibition, and absence of pyruvate designed to unmask the inter-dependence of these genes

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ACSL4 preferentially esterifies certain PUFAs including arachidonic acid and loss of ACSL4 protects cells from ferroptosis induced by direct or indirect inhibition of GPX4 (Fig
Aasi et al