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In vitro, we found that in PSCs, high ROS accumulation attributed to high glucose was associated with PSC activation, which was characterized by increased expression of -SMA, accelerated migration, and increased synthesis of ECM proteins such as collagen I, all of which were rescued by GSH treatment

Hepatic GCGR activation stimulates gluconeogenesis while simultaneously reducing hepatic fat content through inhibition of de novo lipogenesis and promotion of mitochondrial fatty acid oxidation

Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, Emerson SS, Kahn SE, Kitzman DW, Lingvay I, et al

In medical terms, microdosing generally refers to taking a dose lower than the lowest FDA-approved dose of a medication