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PMID: 12209581

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[10] Additive depressant effects occur with other class I antiarrhythmics, phenytoin, and volatile anesthetics, while epinephrine-containing local formulations may potentiate vasoconstriction and delay systemic absorption-beneficial for prolonging local anesthesia but hazardous if inadvertent intravascular injection occurs

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The thiol-based antioxidant NAC has undergone clinical trials for use in respiratory related infections ( In this study, we demonstrated that GSH acidity plays a key role in biofilm disruption of many MDR bacterial isolates and enhances antibiotic efficacy