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Chemistry , 104164 (2022)
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Upregulated: collagen synthesis genes (COL1A1, COL3A1), antioxidant genes (SOD1, SOD3), DNA repair genes (GADD45A) Downregulated: inflammatory cytokines (IL-6, TNF-), metalloproteinases (MMP-2, MMP-9), pro-fibrotic mediators Net effect: shift from tissue destruction and inflammation toward repair and remodeling This breadth of gene modulation is unusual for a single tripeptide and has generated significant research interest in fields ranging from dermatology to neuroscience
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Major cancer centers also note the evidence base is still developing and encourage third-party tested products
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the classic Littlejohns 2014 Neurology cohort (122% higher dementia risk when severely deficient)
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