This endothelial dysfunction decreases the potent vasodilator nitric oxide (NO) in endothelial and vascular muscle smooth cells, increases the levels of vasoconstrictors such as endothelin-1 [13], and creates a hypercoagulable state by activating platelet aggregation and inhibiting fibrinolysis [14]
While medication alone wont solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms. The WHO did qualify its recommendations, saying endorsement is conditional due to limited data on their long-term efficacy and safety, maintenance and discontinuation, their current costs, inadequate health-system preparedness, and potential equity implications. The drugs should not be used by pregnant women, and should be paired with evidence-based interventions like healthy diets and physical activity, the guidelines also stress
For example, in a recent study, menopausal women with obesity or overweight lost more weight when tirzepatide was used along with HRT, and they had better cardiometabolic outcomes
This preparation is intended for research use in biochemical and pharmacological model systems.Not for human use
Six months in now and the transformation in my confidence is just as significant as the physical changes