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However, this cost-saving hack creates a serious safety issue

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They are used with a reduced-calorie diet and increased physical activity to: reduce the risk of major cardiovascular events (death, heart attack, or stroke) in adults with known heart disease and either obesity or overweight

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A key physiological difference between the two incretin hormones, GIP and GLP-1, is therefore, that GIP is able to stimulate glucagon secretion, whereas GLP-1 suppresses glucagon secretion (18)