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The body does not exclusively target fat stores during periods of severe energy restriction

TFEB (facteur de transcription EB), dans des conditions de stress lysosomal induit par des lipides athrognes tels que les LDL oxydes, dclenche la biogense lysosomale, notamment une expression accrue du gne LIPA (Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae 2014)

Its dual action has piqued the interest of many

Its primary mechanism of action involves inhibiting cell growth by forming a complex with topoisomerase II (Ozkan and Bakar-Ates, 2023a) discovered that the combination of etoposide and erastin synergistically induced ferroptosis